Jan Ryerse, Ph.D.

Position: Untitled document

Professor
Director, Research and Confocal Microscopy Cores

Education:
Untitled document University of Western Ontario, Ph.D., 1978

Office: Untitled document Schwitalla Hall

Email Address: ryersejs@slu.edu

CV: Jan Ryerse, Ph.D.

Jan Ryerse, Ph.D.
Jan Ryerse, Ph.D.
Clinical/Research Interests:
Untitled document

Histology and cellular ultrastructure; microscopy, including light, fluorescence, confocal, transmission electron microscopy and scanning electron microscopy; immuno-fluorescence, immuno-peroxidase histochemistry and immuno-gold cytochemistry; microscopy-related collaborative research projects and consultation.



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Division

Research

Departmental Affiliations

Pathology

Lab Images

Publications

1. Fu, Y., Zheng, S., Ryerse, J., Chen, A. (2008) Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol. Pharmacol. 73:399-409.

2. Rickard, A., Beckett, C., Dorokhov, N., Poeschl, M. D., Ryerse, J., Klumpp, D. J., McHowat, J. (2008) Characterization of Tight Junction Proteins in Cultured human urothelial cells. In Vitro Cell. Dev. Biol. Animal, 44:261-267.

3. Gerik, K. J., S. R. Bhimireddy, J. S. Ryerse, C. A. Specht , Lodge J. K. (2008) Protein Kinase C1 (PKC1) is essential for cell integrity, normal manifestation of virulence factors, and protection against both oxidative and nitrosative stress in the pathogenic fungus Cryptococcus neoformans Eukaryotic Cell, 7:1685-1698.

4. Dogrukol-Ak, D., V. B. Kumar, J. S. Ryerse, S. A. Farr, S. Verma, N. Nonaka, T. Nakamachi, H. Ohtaki, M. L. Neihoff, J. C. Edwards, S. Shioda, J. E. Morley and W. A. Banks, W. (2009) Identification of blood-brain barrier transport system for PACAP27: Therapeutic effects in Alzheimer and stroke models. J. Cerebral Blood Flow and Metabolism, 29:411-422.

5. Lomonosova E., Ryerse, J. and Chinnadurai G. (2009) Bax/Bak-independent mitoptosis during cell death induced by proteosome inhibition. Mol. Cancer Res., Mol. Cancer Res. 7:268-284.

6. Muscoli, C, Doyle, T, Dagostino, C, Bryant, L, Chen, Z, Watkins, LR, Ryerse, J, Bieberich, E, Neumman, W and Salvemini, D. (2010). Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids. J. Neuroscience, 30:15400-15408.

7. Timothy Doyle, Zhoumou Chen, Carolina Muscoli, Leesa Bryant, Emanuela Esposito, Salvatore Cuzzocrea, Concetta Dagostino, Jan Ryerse, Smita Rausaria, Andrew Kamadulski, William L. Neumann and Daniela Salvemini. (2012) Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain. J. NeuroSci., 32:6149-6160.

8. Doghu, S., Ryerse, J. S., Robinson, S. M. and William M. Banks (2012) Human immunodeficiency virus-1uses the mannose-6-phosphate receptor to cross the blood-brain barrier. PLoS One. 2012;7(6):e39565. Epub 2012 Jun 25.

9. El-Achkar, Tarek; McCracken, Ruth; Liu, Yan; Heitmeier, Monique; Bourgeois, Soline; Ryerse, Jan; Wu, Xue-Ru (2013) Tamm-Horsfall Protein Translocates to the Basolateral Domain of Thick Ascending Limbs, Interstitium and Circulation during Recovery from Acute Kidney Injury" (F-00543-2012R1), American Journal of Physiology, Renal Physiology, In Press.

10. Eriko Yasuda, Kazunari Fushimi, Yasuyuki Suzuki, Katsuji Shimizu, Tsuyoshi Takami, Jozef Zustin, Pravin Patel,  Kristen Ruhnke, Tsutomu Shimada, Bobbie Boyce, Terry Kokas, Carol Barone, Mary Theroux, William Mackenzie, Barbara Nagel, Jan S. Ryerse, Kenji Orii, Hiroki Iida, Tadao Orii, Shunji Tomatsu.  (2013) Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder. Molecular Genetics and Metabolism. In press.


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