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Jianguo Liu, M.D., Ph.D.

Professor, Division of Infectious Diseases, Allergy and Immunology
Department of Internal Medicine

Professor
Department of Molecular Microbiology and Immunology

Courses Taught

Microbes and Host Responses (MHR); Immunobiology MBG-665

Education

M.D., Ph.D.

Research Interests

Jianguo Liu, M.D., Ph.D., is working on the mechanisms of host-pathogen interaction and has made a significant contribution to our understanding of the immune evasion mechanisms of Mycobacterium Tuberculosis in macrophages regulated by RNA-binding proteins. Liu also works on understanding of the role of RNA-binding proteins in the development and progression of breast cancer. Ongoing efforts in Liu's lab are to develop new host-directed therapies and vaccines to boost protective immunity for treatment of Mtb and breast cancer.

Labs and Facilities

  • Edward A Doisy Research Center: 863, 861B and 858B

Publications and Media Placements

Jidong Zhang, Xuesong Qian, Huan Ning, Christopher S. Eickhoff, Daniel F. Hoft, and Jianguo Liu. Transcriptional suppression of interleukin-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding. J Immunol 2011; 186(10): 5885-95. 

Wenbao Lu, Huan Ning, Ling Gu, Hui Peng, Qinghong Wang, Rong Hou, Mingui Fu, Daniel F. Hoft and Jianguo Liu. MCPIP1 selectively destabilizes transcripts associated with an anti-apoptotic gene expression program in breast cancer cells that can elicit complete tumor regression. Cancer Research 2016; 15;76(6): 1429-40.

Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F. Hoft and Jianguo Liu. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nature Communications 2017; 11; 8(1):867.

Hui Peng, Huan Ning, Qinghong Wang, Wenbao Lu, Yingzi Chang, Pappachan E. Kolattukudy, Tianyi Wang, Rong Hou, Daniel F. Hoft, Mark S. Dykewicz and Jianguo Liu. MCPIP1 controls allergic airway inflammation by suppressing IL-5-producing Th2 cells through Notch/Gata3 pathway. Journal of Allergy and Clinical Immunology 2018; 142(2):582-594.

Hui Peng, Huan Ning, Qinghong Wang, Jinping Lai, Lin Wei, Deborah J. Stumpo, Perry J. Blackshear, Mingui Fu, Rong Hou, Daniel F. Hoft and Jianguo Liu. Tristetraprolin Regulates TH17 Cell Function and Ameliorates DSS-Induced Colitis in Mice. Front Immunol. 2020; 11: 1952. Published 2020 Aug 14. doi:10.3389/fimmu.2020.01952

Jiawei Wei, Huan Ning, Octavio Ramos-Espinosa, Christopher S. Eickhoff, Rong Hou, Qinghong Wang, Mingui Fu, Ethan Y. Liu, Daping Fan, Daniel F. Hoft and Jianguo Liu. Tristetraprolin mediates immune evasion of mycobacterial infection in macrophages. FASEB Bioadv 2024; 29; 6(8): 249-262.

Honors and Awards

  • The NCI Transition Career Development Award
  • Cynthia Chambers Memorial-eBiosciences Junior Faculty Award
  • President Research Awards
  • ICTS award
  • NIH