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Division of Rheumatology

Saint Louis University School of Medicine's Division of Rheumatology specializes in the care of both adults and children with disorders affecting joints, muscles and connective tissues. 

Restoring Joint Health and Mobility

Rheumatology is a combined Internal Medicine-Pediatrics division that serves both adults and children. Physicians manage the care of people with connective tissue diseases, including rheumatoid arthritis, juvenile rheumatoid arthritis and systemic lupus. 

The division is known for its outstanding clinical care, education and research, boasting impressive stats that include:

  • First clinic in eastern Missouri for children and adults with rheumatic diseases
  • Five-year, NIH-funded RO1 lupus research grant
  • More than 2,000 patients treated each year

Fellowship training programs for both adult and pediatric rheumatology are available. 

Meet the Faculty

Rheumatology Research

The division conducts extensive research. Priority projects include:

  • Juvenile idiopathic arthritis and isotypes of Anti-CCP antibodies
  • Rheumatoid factors and glycosylation
  • Systemic lupus and
    • Regulatory T-cells
    • Interferon signatures
    • Syk and immune complexes
Recent Studies
  • R01 NIH grant for lupus research
    Principal investigator: Anil Chauhan, Ph.D.
    Co-principle investigator: Terry L. Moore, M.D.
    $375,000/year
  • Lupus and juvenile arthritis research
    Principal investigator: Terry L. Moore, M.D.
    $25,000/year
  • Juvenile arthritis research award
    Principal investigator: Terry L. Moore, M.D.
    $25,000/year
  • Corrona: Data Collection Program
    Principal investigator: Peri Pepmueller, M.D.
  • Childhood Arthritis and Research Alliance Network (CARRANet)
    Accelerating Toward an Evidence-Based Culture in Pediatric Rheumatology: CARRA Registry
    Principal investigator: Reema Syed, M.D.
  • An Observational Registry of Abatecept in Patients with Juvenile Idiopathic Arthritis
    Principal investigator: Reema Syed, M.D.
  • BENLYSTA™ Study
    Five-Year Prospective Observational Registry to Access Adverse Events of Interest and Effectiveness in Adults with Active, Autoantibody-Positive Systemic Lupus Erythematosus Treated With or Without BENLYSTA™ (Belimumab)
    Principal investigator: Reema Syed, M.D.
Publications
  • Moore TL: Juvenile idiopathic arthritis. In: "Conn's Current Therapy 2009", (eds) RE Rakel, ET Bope, pp 983-986, 2009
  • Low JM, Chauhan AK, Gibson DS, Zhu M, Chen S, Rooney ME, Ombrello MJ, Moore TL: Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease associated proteins. Proteomics Clin App 3: 829-840, 2009
  • Reed MR, Gilliam BE, Syed RH, Moore TL: Rheumatic manifestation of Parvovirus B19 in children. J Pediatr Infect Dis 4: 321-331, 2009
  • Gilliam BE, Reed MR, Syed RH, Moore TL: Rheumatic manifestation of Epstein-Barr virus in children. J Pediatr Infect Dis 4: 333-342, 2009
  • Moore TL: Juvenile idiopathic arthritis. In "Conn's Current Therapy 2010," (eds) RE Rakel, ET Bope, Kellerman R, pp 987-989, 2010
  • Gilliam BE, Reed MR, Chauhan AK, Dehlendorf AB, Moore TL: Evidence of fibrinogen as a target of citrullination in IgM rheumatoid factor positive polyarticular juvenile idiopathic arthritis. Pediatr Rheumatol 9: 8: 1-16, 2011
  • Moore TL: Pathogenesis and diagnosis of viral arthritis: Update. Up to Date Rheumatol 19: 1-10, 2011-2014
  • Moore TL, Syed RH: Specific viruses that cause arthritis: Update. Up to Date Rheumatol 19: 1-18, 2011-2014
  • Chauhan AK, Moore TL: T-cell activation by the terminal complex of complement and immune complexes. J Biol Chem 287: 38627-38637, 2011
  • Gilliam BE, Reed MR, Chauhan AK, Dehlendorf AB, Moore TL: Significance of complement components Clq and C4 bound to circulating immune complexes in juvenile idiopathic arthritis: Support for classical complement pathway activation. Clin Exp Rheumatol 29: 1049-1056, 2011
  • Chauhan AK, Moore TL: Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4+ T cells. Clin Exp Immunol 167: 235-245, 2012
  • Gilliam BE, Ombrello AK, Burlingame R, Pepmueller PH, Moore TL; Measurement of autoantibodies in pediatric and adolescent-onset systemic lupus erythematosus and their significant relationship with disease-associated manifestations. Semin Arthritis Rheum 41: 840-848, 2012
  • Moore TL: Diseases of the joints. In Pathy's "Principles and Practice of Geriatric Medicine", eds JE Morley, AJ Sinclair, B Velles (5th Edition), pp 1145-1152, 2012
  • Gilliam BE, Moore TL: The role of anti-cyclic citrullinated peptide (CCP) antibodies in early detection of rheumatoid arthritis: an overview of the INOVA Diagnostics, Inc. QUANTA lite CCP Assays. Expert Opin Med Diagn 10: 359-369, 2012 (PMed 23480744)
  • Gibson DS, Newell K, Evans AN, Finnegan S, Manning G, Scaife C, McAllister C, Pennington SR, Duncan MW, Moore TL, Rooney ME: Vitamin D binding protein isoforms as candidate predictors of disease extension in childhood arthritis. J Proteomics 10:1016-1029, 2012 (PMed 22771520)
  • Gilliam BE, Chauhan AK, Moore TL: Evaluation of anti-cyclic citrullinated type II collagen and anti-cyclic citrullinated vimentin autoantibodies in patients with juvenile idiopathic arthritis. Pediatr Rheumatol 11: 31:1-10, 2013 (PMed 23987731)
  • Syed R, Moore TL: Juvenile idiopathic arthritis: pathogenesis, presentation, and treatment, In "Encyclopedia of Medical Immunology", eds G Tsokos, IR Mackay, NR Rose, in press, 2013
  • Moore TL, Gilliam BE, Crespo-Pagnussats, Feller L, Chauhan AK: Measurement and evaluation of isotypes of anti-citrullinated fibrinogen and anti-citrullinated ?-enolase antibodies in juvenile idiopathic arthritis. Clin Exp Rheumatol 32: in press, 2014.
  • Chauhan AK, Chen C, Moore TL, DiPaolo RJ: Induced expression of Fc?RIIIa (CD16a) (CD/Ga) on CD4+ T cells triggers generation of IFN? high subset. J Biol Chem 290, in press, 2015.
  • Dalrymple AM, Moore TL: Laboratory evaluation in pediatric autoimmune disease. Ped Rev, in press, 2015.